The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling

Details

Serval ID
serval:BIB_6ECFAC6DA016
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling
Journal
Developmental Biology
Author(s)
Komine  O., Nagaoka  M., Watase  K., Gutmann  D. H., Tanigaki  K., Honjo  T., Radtke  F., Saito  T., Chiba  S., Tanaka  K.
ISSN
0012-1606 (Print)
Publication state
Published
Issued date
08/2007
Notes
Journal article --- Old month value: Aug 31
Abstract
The Bergmann glia is a unipolar astrocyte in the cerebellar cortex, displaying a tight association with Purkinje cells. The cell bodies of Bergmann glia are located in a row around Purkinje cell somata; they extend radially arranged Bergmann fibers which enwrap the synapses on the Purkinje cell dendrites. It is well known that Bergmann glial somata migrate from the ventricular zone through the mantle zone, forming an epithelium-like lining in the Purkinje cell layer during development. However, the mechanism of the monolayer formation of Bergmann glia is poorly understood. Several reports have suggested that Notch signaling plays instructive roles in promoting the identities of several types of glial cells, including Bergmann glia. Moreover, Notch receptors are expressed in Bergmann glia during development. Here, we have deleted the Notch1, Notch2 and RBP-J genes in the Bergmann glia by GFAP-driven, Cre-mediated recombination, to study the role of Notch-RBP-J-signaling in the monolayer formation of Bergmann glia. Notch1/2- and RBP-J-conditional mutant mice showed disorganization of Bergmann fibers, irregularities of the Bergmann glial lining and aberrant localization of Bergmann glia in the molecular layer. Thus, Notch-RBP-J signaling plays crucial roles in the monolayer formation and morphogenesis of Bergmann glia.
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:39
Last modification date
20/08/2019 14:27
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