The specificity of the familial aggregation of early-onset bipolar disorder: A controlled 10-year follow-up study of offspring of parents with mood disorders.

Détails

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Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_6EB79B96C182
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The specificity of the familial aggregation of early-onset bipolar disorder: A controlled 10-year follow-up study of offspring of parents with mood disorders.
Périodique
Journal of Affective Disorders
Auteur(s)
Preisig M., Strippoli M.P., Castelao E., Merikangas K.R., Gholam-Rezaee M., Marquet P., Aubry J.M., Vandeleur C.L.
ISSN
1573-2517 (Electronic)
ISSN-L
0165-0327
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
190
Pages
26-33
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
BACKGROUND: Two major sources of heterogeneity of mood disorders that have been demonstrated in clinical, family and genetic studies are the mood disorder subtype (i.e. bipolar (BPD) and major depressive disorder (MDD)) and age of onset of mood episodes. Using a prospective high-risk study design, our aims were to test the specificity of the parent-child transmission of BPD and MDD and to establish the risk of psychopathology in offspring in function of the age of onset of the parental disorder.
METHODS: Clinical information was collected on 208 probands (n=81 with BPD, n=64 with MDD, n=63 medical controls) as well as their 202 spouses and 372 children aged 6-17 years at study entry. Parents and children were directly interviewed every 3 years (mean duration of follow-up=10.6 years). Parental age of onset was dichotomized at age 21.
RESULTS: Offspring of parents with early onset BPD entailed a higher risk of BPD HR=7.9(1.8-34.6) and substance use disorders HR=5.0(1.1-21.9) than those with later onset and controls. Depressive disorders were not significantly increased in offspring regardless of parental mood disorder subtype or age of onset.
LIMITATIONS: Limited sample size, age of onset in probands was obtained retrospectively, age of onset in co-parents was not adequately documented, and a quarter of the children had no direct interview.
CONCLUSIONS: Our results provide support for the independence of familial aggregation of BPD from MDD and the heterogeneity of BPD based on patterns of onset. Future studies should further investigate correlates of early versus later onset BPD.
Mots-clé
Adolescent, Adult, Age of Onset, Bipolar Disorder/genetics, Child, Child of Impaired Parents/psychology, Depressive Disorder, Major/genetics, Family Health, Female, Follow-Up Studies, Humans, Male, Prospective Studies, Risk Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/10/2015 14:33
Dernière modification de la notice
27/09/2019 8:57
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