The Effect of Balancing Selection on Population Differentiation: A Study with HLA Genes.

Détails

Ressource 1Télécharger: 2805.full.pdf (1297.47 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_6EA8F8E383C5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The Effect of Balancing Selection on Population Differentiation: A Study with HLA Genes.
Périodique
G3
Auteur(s)
Brandt DYC, César J., Goudet J., Meyer D.
ISSN
2160-1836 (Electronic)
ISSN-L
2160-1836
Statut éditorial
Publié
Date de publication
31/07/2018
Peer-reviewed
Oui
Volume
8
Numéro
8
Pages
2805-2815
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Balancing selection is defined as a class of selective regimes that maintain polymorphism above what is expected under neutrality. Theory predicts that balancing selection reduces population differentiation, as measured by FST. However, balancing selection regimes in which different sets of alleles are maintained in different populations could increase population differentiation. To tackle the connection between balancing selection and population differentiation, we investigated population differentiation at the HLA genes, which constitute the most striking example of balancing selection in humans. We found that population differentiation of single nucleotide polymorphisms (SNPs) at the HLA genes is on average lower than that of SNPs in other genomic regions. We show that these results require using a computation that accounts for the dependence of FST on allele frequencies. However, in pairs of closely related populations, where genome-wide differentiation is low, differentiation at HLA is higher than in other genomic regions. Such increased population differentiation at HLA genes for recently diverged population pairs was reproduced in simulations of overdominant selection, as long as the fitness of the homozygotes differs between the diverging populations. The results give insight into a possible "divergent overdominance" mechanism for the nature of balancing selection on HLA genes across human populations.
Mots-clé
Algorithms, Alleles, Evolution, Molecular, Gene Frequency, Genetics, Population, HLA Antigens/genetics, Haplotypes, Humans, Models, Genetic, Polymorphism, Single Nucleotide, Selection, Genetic, HLA, balancing selection, population differentiation
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/06/2018 16:59
Dernière modification de la notice
08/05/2019 20:09
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