Variant differentiation patterns in primary liver carcinoma.

Details

Serval ID
serval:BIB_6EA0225F052D
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Variant differentiation patterns in primary liver carcinoma.
Journal
Seminars in diagnostic pathology
Author(s)
Sempoux C., Paradis V., Saxena R.
ISSN
0740-2570 (Print)
ISSN-L
0740-2570
Publication state
Published
Issued date
03/2017
Peer-reviewed
Oui
Volume
34
Number
2
Pages
176-182
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Typé Bibliomics
Abstract
Hepatocellular carcinoma and intrahepatic cholangiocarcinoma are two distinct forms of primary liver carcinoma recognizable at the microscope by their architectural and cytological characteristics, as well as specific immunohistochemical profiles. This straightforward concept however, is increasing imperiled by the recognition of primary liver carcinomas that do not subscribe to a dichotomous paradigm of differentiation, and instead demonstrate biphenotypic differentiation, stem/progenitor cell like features or other variant patterns of differentiation. Appropriate nomenclature, diagnostic criteria, prognostic significance and optimal therapeutic approach for these variant tumors are not completely defined, not leasyt because they are not always identified correctly and when they are, lack of uniform terminology hinders collection of adequate number of cases to facilitate their study. Similar to hepatocellular carcinoma and in contrast with intrahepatic cholangiocarcinoma, primary liver tumors showing biphenotypic differentiation, stem/progenitor cell features or variant differentiation occur mainly, but not always, on a background of chronic liver disease. They are particularly frequent after neo-adjuvant therapy. Whether they represent trans-differentiation of malignant cells, or whether they derive from a stem/progenitor cell that gives rise to divergent differentiation remains yet another area of uncertainty.

Keywords
Adult, Aged, Bile Duct Neoplasms/pathology, Bile Ducts, Intrahepatic/pathology, Carcinoma, Hepatocellular/pathology, Cell Differentiation, Cholangiocarcinoma/pathology, Female, Humans, Liver Neoplasms/pathology, Male, Middle Aged, Bi-phenotypic differentiation, Cholangiocarcinoma, Cholangiolocellular carcinoma, Combined hepatocellular-cholangiocarcinoma, Combined primary liver carcinoma, Hepatocellular carcinoma, Mixed primary liver carcinoma, Progenitor cells, Stem cells, Trans-differentiation
Pubmed
Web of science
Create date
06/03/2017 9:46
Last modification date
20/08/2019 14:27
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