Pyroptosis: Caspase-11 Unlocks the Gates of Death.

de Gassart, A.; Martinon, F.

doi:10.1016/j.immuni.2015.10.024

Pyroptosis: Caspase-11 Unlocks the Gates of Death.

Details

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Serval ID

serval:BIB_6E958EED3865

Type

Article: article from journal or magazin.

Publication sub-type

Editorial

Collection

Publications

Institution

UNIL/CHUV

Title

Pyroptosis: Caspase-11 Unlocks the Gates of Death.

Journal

Immunity

Author(s)

de Gassart A., Martinon F.

ISSN

1097-4180 (Electronic)

ISSN-L

1074-7613

Publication state

Published

Issued date

2015

Volume

Number

Pages

835-837

Language

english

Notes

Publication types: Journal Article Publication Status: ppublish

Abstract

How inflammatory caspases trigger pyroptotic cell death is mostly unexplained. In this issue of Immunity, Núñez and colleagues report that caspase-11 cleaves the transmembrane channel pannexin-1, causing an efflux of cellular ATP that promotes a P2X7 receptor-dependent pyroptosis.

OAI-PMH

oai:serval.unil.ch:BIB_6E958EED3865

DOI

10.1016/j.immuni.2015.10.024

Pubmed

26588774

Web of science

000366846000003

Open Access

Yes

Create date

07/12/2015 12:06