Primetime for antiangiogenic therapy.

Details

Serval ID
serval:BIB_6E952EBF88AE
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Primetime for antiangiogenic therapy.
Journal
Current Opinion In Neurology
Author(s)
Tabatabai G., Stupp R.
ISSN
1473-6551[electronic], 1080-8248[linking]
Publication state
Published
Issued date
2009
Volume
22
Number
6
Pages
639-644
Language
english
Abstract
PURPOSE OF REVIEW: To review the current experience with angiogenesis inhibitors in the treatment of gliomas.
RECENT FINDINGS: Antiangiogenic therapy has recently reached the clinic with the approval of bevacizumab for recurrent glioblastomas. A number of promising antiangiogenic and vasculature-modifying agents are under investigation for newly diagnosed and recurrent malignant gliomas. A recurrence under ongoing or after antiangiogenic therapy is often characterized by a more aggressive and, in particular, invasive phenotype.
SUMMARY: Despite impressively high radiological response rates in patients with recurrent malignant glioma, the duration of response is usually short-lived, and the observed effect to a large extent may be due to normalization of the disrupted blood-brain barrier and less due to a direct antitumor effect. Overall survival remains poor. Induction of invasive phenotypes and escape with proangiogenic alternative pathways are contributing to resistance. Investigation of combination regimes targeting several pathways will determine the possibilities to overcome the resistance to antiangiogenic therapy in malignant gliomas. This article summarizes the results of recent clinical trials in this field, points towards mechanisms of resistance arising under angiogenesis inhibition and discusses the challenges for the future.
Keywords
Angiogenesis, Antiangiogenic Therapy, Malignant Glioma, Endothelial Growth-Factor, Recurrent Glioblastoma-Multiforme, Bevacizumab Plus Irinotecan, Anti-Angiogenic Therapy, Brain-Tumor Growth, Cancer Stem-Cells, In-Vivo, Integrin Inhibitors, Perivascular Niche, Malignant Gliomas
Pubmed
Web of science
Create date
21/12/2009 15:51
Last modification date
20/08/2019 14:27
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