Stopping Denosumab.

Détails

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Etat: Public
Version: de l'auteur
Licence: Non spécifiée
ID Serval
serval:BIB_6E92DA5E8472
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Stopping Denosumab.
Périodique
Current osteoporosis reports
Auteur(s)
Lamy O., Stoll D., Aubry-Rozier B., Gonzalez Rodriguez E.
ISSN
1544-2241 (Electronic)
ISSN-L
1544-1873
Statut éditorial
Publié
Date de publication
02/2019
Peer-reviewed
Oui
Volume
17
Numéro
1
Pages
8-15
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Denosumab discontinuation is associated with a rebound effect manifesting by an increased risk of multiple spontaneous vertebral fractures. The purpose of this review is to (1) better characterize this risk and (2) find solutions to avoid it.
In the absence of a potent bisphosphonate prescription at denosumab discontinuation, the frequency of multiple vertebral fractures is common or frequent (≥ 1/100 and < 1/10). In five recent case series, the median number of vertebral fractures was 5 within 7 to 20 months (median 11) after the last denosumab injection. Prescribing bisphosphonate before starting denosumab and/or after stopping denosumab may reduce this risk. However, only small case series have evaluated these strategies. After the second denosumab dose, there is a rebound effect with an increased risk of multiple vertebral fractures. A potent bisphosphonate prescribed at denosumab discontinuation could reduce this risk. As denosumab discontinuation is characterized by many uncertainties, denosumab is a second-line treatment for osteoporosis. Studies are urgently needed to define the management of denosumab discontinuation.
Mots-clé
Denosumab discontinuation, Osteoporosis, Rebound effect, Spontaneous multiple vertebral fractures
Pubmed
Web of science
Création de la notice
28/01/2019 9:09
Dernière modification de la notice
03/02/2020 15:12
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