Effects of pro-cholinergic treatment in patients suffering from spatial neglect.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_6DC4BF65AE7D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effects of pro-cholinergic treatment in patients suffering from spatial neglect.
Périodique
Frontiers in Human Neuroscience
Auteur(s)
Lucas N., Saj A., Schwartz S., Ptak R., Schnider A., Thomas C., Conne P., Leroy R., Pavin S., Diserens K., Vuilleumier P.
ISSN
1662-5161 (Electronic)
ISSN-L
1662-5161
Statut éditorial
Publié
Date de publication
2013
Volume
7
Numéro
574
Pages
1-15
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: epublish
Résumé
Spatial neglect is a neurological condition characterized by a breakdown of spatial cognition contralateral to hemispheric damage. Deficits in spatial attention toward the contralesional side are considered to be central to this syndrome. Brain lesions typically involve right fronto-parietal cortices mediating attentional functions and subcortical connections in underlying white matter. Convergent findings from neuroimaging and behavioral studies in both animals and humans suggest that the cholinergic system might also be critically implicated in selective attention by modulating cortical function via widespread projections from the basal forebrain. Here we asked whether deficits in spatial attention associated with neglect could partly result from a cholinergic deafferentation of cortical areas subserving attentional functions, and whether such disturbances could be alleviated by pro-cholinergic therapy. We examined the effect of a single-dose transdermal nicotine treatment on spatial neglect in 10 stroke patients in a double-blind placebo-controlled protocol, using a standardized battery of neglect tests. Nicotine-induced systematic improvement on cancellation tasks and facilitated orienting to single visual targets, but had no significant effect on other tests. These results support a global effect of nicotine on attention and arousal, but no effect on other spatial mechanisms impaired in neglect.
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/10/2013 17:59
Dernière modification de la notice
20/08/2019 15:27
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