Prolactin and the gut: a controversy

Details

Serval ID
serval:BIB_6D622A6B8666
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prolactin and the gut: a controversy
Journal
Journal of Pediatric Gastroenterology and Nutrition
Author(s)
Theintz  G. E., Nussle  D., Cox  J., Carmignac  D., Duhamel  D., Sizonenko  P. C.
ISSN
0277-2116 (Print)
Publication state
Published
Issued date
09/1984
Volume
3
Number
4
Pages
523-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
Previous reports suggest that prolactin could be one of the factors controlling intestinal mucosal growth. Therefore plasma levels of prolactin have been measured at the time of jejunal biopsy performed for suspicion of celiac disease. One hundred eighty-seven biopsies from 166 children have been reviewed according to histology, age, diagnosis, and plasma prolactin. No difference in the plasma prolactin could be detected among a group of 117 normal biopsies (9.4 +/- 0.4 ng/ml, mean +/- SEM), 31 biopsies with partial atrophy of various degree (9.0 +/- 0.9 ng/ml), and 39 biopsies with flat mucosa (9.1 +/- 0.7 ng/ml), nor could we demonstrate an increase in prolactin according to age and diagnosis (celiac disease before and after treatment, cow's milk protein intolerance, isolated postenteritic syndrome, selective sugar intolerance, and functional gut problems). Prolactinlike material has been detected by immunoperoxidase in the jejunal mucosa. The intracellular granules are located in the infranuclear portion of isolated epithelial cells mainly in the crypts. This material could not be correlated with the corresponding prolactinemias, whatever the histological appearance of the mucosa. These results would suggest that plasma prolactin is not a marker of jejunal regeneration in children. The nature and function(s) of this prolactinlike material remain to be established.
Keywords
Adolescent Adult Biopsy Celiac Disease/*metabolism/pathology Child Child, Preschool Cytoplasmic Granules/analysis Female Humans Immunoenzyme Techniques Infant Intestinal Mucosa/growth & development/*metabolism/pathology Jejunum/*metabolism/pathology Male Prolactin/analysis/blood/*physiology
Pubmed
Web of science
Create date
25/01/2008 10:30
Last modification date
20/08/2019 14:27
Usage data