Selection of patients with advanced-stage cervical cancer for para-aortic lymphadenectomy in the era of PET/CT.
Details
Serval ID
serval:BIB_6D2C35CBD47D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Selection of patients with advanced-stage cervical cancer for para-aortic lymphadenectomy in the era of PET/CT.
Journal
Anticancer Research
ISSN
1791-7530 (Electronic)
ISSN-L
0250-7005
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
33
Number
1
Pages
283-286
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
BACKGROUND: The aim of this study was to report the false-negative rate of positron-emission tomography (PET) /Computed Tomography (CT) for para-aortic (PA) lymph node (LN) metastasis and to examine if PA lymphadenectomy could be omitted when PET/CT of the pelvic area is negative.
PATIENTS AND METHODS: Patients without evidence of extrapelvic disease on preoperative imaging or in the PA area were included. Each patient underwent a laparoscopic PA lymphadenectomy.
RESULTS: A total of 61 patients were included. Seven patients (11%) had PALN metastasis. The false-negative rate of PET/CT was 11%. When PET/CT was positive for pelvic nodes, the risk for PA metastasis was 18% versus 8% when PET/CT was negative in the pelvic area (p=0.24).
CONCLUSION: The apparent low sensitivity of the PET/CT does not make it a relevant alternative to surgical LN staging when no uptake is visualized in the PA area. However, for patients in whom PET/CT is negative in the pelvic area, the risk of metastasis in the PA area is low.
PATIENTS AND METHODS: Patients without evidence of extrapelvic disease on preoperative imaging or in the PA area were included. Each patient underwent a laparoscopic PA lymphadenectomy.
RESULTS: A total of 61 patients were included. Seven patients (11%) had PALN metastasis. The false-negative rate of PET/CT was 11%. When PET/CT was positive for pelvic nodes, the risk for PA metastasis was 18% versus 8% when PET/CT was negative in the pelvic area (p=0.24).
CONCLUSION: The apparent low sensitivity of the PET/CT does not make it a relevant alternative to surgical LN staging when no uptake is visualized in the PA area. However, for patients in whom PET/CT is negative in the pelvic area, the risk of metastasis in the PA area is low.
Keywords
Adult, Aged, Aorta/pathology, Aorta/surgery, Female, Humans, Laparoscopy, Lymph Node Excision, Lymph Nodes/pathology, Lymph Nodes/surgery, Lymphatic Metastasis/pathology, Lymphatic Metastasis/radiography, Middle Aged, Multimodal Imaging, Neoplasm Staging, Pelvis/pathology, Pelvis/surgery, Positron-Emission Tomography, Survival Rate, Tomography, X-Ray Computed, Uterine Cervical Neoplasms/pathology, Uterine Cervical Neoplasms/radiography
Pubmed
Web of science
Create date
13/10/2015 10:16
Last modification date
20/08/2019 14:26
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