Erythropoietin for the Repair of Cerebral Injury in Very Preterm Infants (EpoRepair).
Details
Serval ID
serval:BIB_6D0FF6F865D5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Erythropoietin for the Repair of Cerebral Injury in Very Preterm Infants (EpoRepair).
Journal
Neonatology
Working group(s)
EpoRepair Investigators
Contributor(s)
Meyer P., Konetzny G., Kasser S., Schulzke SM., Nelle M., Gerull R., Bär W., Scharrer B., Truttmann AC., Tolsa JF., Rogdo B., Hoigne I., Fauchère JC., Natalucci G., Koller B., Knöpfli C., Bührer C., Dame C., Koluch A., Hoffmann I., Hentschel R., Fuchs H., Franz AR., Poets CF., Arand J., Klebermass-Schrehof K., Berger A., Kreissl A., Held L., Sick B.
ISSN
1661-7819 (Electronic)
ISSN-L
1661-7800
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
108
Number
3
Pages
198-204
Language
english
Abstract
BACKGROUND: Preterm infants suffering from intraventricular hemorrhage (IVH) are at increased risk for neurodevelopmental impairment. Observational data suggest that recombinant human erythropoietin (rEPO) improves long-term cognitive outcome in infants with IVH. Recent studies revealed a beneficial effect of early high-dose rEPO on white matter development in preterm infants determined by magnetic resonance imaging (MRI).
OBJECTIVES: To summarize the current evidence and to delineate the study protocol of the EpoRepair trial (Erythropoietin for the Repair of Cerebral Injury in Very Preterm Infants).
METHODS: The study involves a review of the literature and the design of a double-blind, placebo-controlled, multicenter trial of repetitive high-dose rEPO administration, enrolling 120 very preterm infants with moderate-to-severe IVH diagnosed by cranial ultrasound in the first days of life, qualitative and quantitative MRI at term-equivalent age and long-term neurodevelopmental follow-up until 5 years of age.
RESULTS AND CONCLUSIONS: The hypothesis generated by observational data that rEPO may improve long-term cognitive outcomes of preterm infants suffering from IVH are to be confirmed or refuted by the randomized controlled trial, EpoRepair.
OBJECTIVES: To summarize the current evidence and to delineate the study protocol of the EpoRepair trial (Erythropoietin for the Repair of Cerebral Injury in Very Preterm Infants).
METHODS: The study involves a review of the literature and the design of a double-blind, placebo-controlled, multicenter trial of repetitive high-dose rEPO administration, enrolling 120 very preterm infants with moderate-to-severe IVH diagnosed by cranial ultrasound in the first days of life, qualitative and quantitative MRI at term-equivalent age and long-term neurodevelopmental follow-up until 5 years of age.
RESULTS AND CONCLUSIONS: The hypothesis generated by observational data that rEPO may improve long-term cognitive outcomes of preterm infants suffering from IVH are to be confirmed or refuted by the randomized controlled trial, EpoRepair.
Pubmed
Open Access
Yes
Create date
18/01/2016 15:53
Last modification date
20/08/2019 15:26
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