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Functional role of Notch signaling in the developing and postnatal heart
Journal of Molecular and Cellular Cardiology
In the developing heart, Notch signaling plays an essential role in several key developmental processes, such as epithelial-to-mesenchymal transition and myocyte proliferation and differentiation. The importance of Notch in cardiac development has been demonstrated in knockout mice carrying null mutations in genes encoding components of the Notch pathway. Furthermore, humans with inactivating mutations in the Notch ligand Jagged1 suffer from Alagille syndrome, a condition characterized by several cardiac defects. Notch1 receptor haploinsufficiency has also been involved in aortic valve disease in humans. In addition, accumulating evidence indicates that Notch may also regulate homeostasis in the adult heart. Notch may protect the heart from an excessive and detrimental hypertrophic response and increase cardiomyocyte survival. Emerging evidence also suggests that Notch could be important for cardiac tissue renewal by controlling the maintenance and commitment of a cardiac stem cell compartment.
Adult , Alagille Syndrome , Animals , Calcium-Binding Proteins , Cardiomegaly , genetics , growth & development , Heart , Heart Valve Diseases , Homeostasis , Humans , Intercellular Signaling Peptides and Proteins , Membrane Proteins , metabolism , Mice , Mice,Knockout , Mutation , Peptides , Proteins , Receptors,Notch , Signal Transduction , Stem Cells , Survival , Switzerland
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