Peroxisome proliferator-activated receptors A link between endocrinology and nutrition?

Details

Serval ID
serval:BIB_6CE86AD01278
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Peroxisome proliferator-activated receptors A link between endocrinology and nutrition?
Journal
Trends in Endocrinology and Metabolism
Author(s)
Keller H., Wahli W.
ISSN
1043-2760 (Print)
ISSN-L
1043-2760
Publication state
Published
Issued date
1993
Peer-reviewed
Oui
Volume
4
Number
9
Pages
291-296
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily like the steroid, thyroid, or retinoid hormone receptors, which are ligand-activated transcription factors regulating gene expression. PPARs mediate the induction of the enzymes of the peroxisomal and microsomal fatty-acid oxidation pathways by hypolipidemic drugs such as clofibrate and are probably also involved in the gene expression of other lipid-metabolism-associated proteins that are controlled by fibrate hypolipidemic drugs. That PPARs play an important role in the regulation of lipid metabolism is reinforced by the discovery of their activation by physiologic concentrations of fatty acids. This observation raises the question of whether fatty acids are ligands of PPARs, which would imply that nutritional fatty acids can act like hormones.
Pubmed
Web of science
Create date
06/07/2009 13:03
Last modification date
20/08/2019 14:26
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