Definition of Uveitis Refractory to Treatment: A Systematic Review in the Absence of a Consensus.
Details
Serval ID
serval:BIB_6C8B4116C2A5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Definition of Uveitis Refractory to Treatment: A Systematic Review in the Absence of a Consensus.
Journal
Ocular immunology and inflammation
ISSN
1744-5078 (Electronic)
ISSN-L
0927-3948
Publication state
Published
Issued date
02/01/2022
Peer-reviewed
Oui
Volume
30
Number
1
Pages
174-179
Language
english
Notes
Publication types: Journal Article ; Systematic Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
To evaluate the different definition of refractoriness in uveitis in the literature.
We systematically searched the literature in order to identify definitions of refractory noninfectious uveitis in adult patients. A search strategy in the databases of MEDLINE and Scopus was used to find articles published between January 2005 and October 2018.
Definitions of corticosteroids-refractoriness were related to two main concepts: persistence of inflammation despite the use of corticosteroid and recurrences above a dosage threshold. In terms of immunomodulatory therapy and biologic agents, we observed a great variety of definitions: persistence of inflammation, number of attacks, side effects or complications, symptoms, and best-corrected visual acuity.
The results of this systematic review demonstrate the current lack of consensus on the definition for refractory uveitis, regardless of the treatment being used and revealed a new terminology based on a comprehensive and operational definition for each specific category of refractoriness.
We systematically searched the literature in order to identify definitions of refractory noninfectious uveitis in adult patients. A search strategy in the databases of MEDLINE and Scopus was used to find articles published between January 2005 and October 2018.
Definitions of corticosteroids-refractoriness were related to two main concepts: persistence of inflammation despite the use of corticosteroid and recurrences above a dosage threshold. In terms of immunomodulatory therapy and biologic agents, we observed a great variety of definitions: persistence of inflammation, number of attacks, side effects or complications, symptoms, and best-corrected visual acuity.
The results of this systematic review demonstrate the current lack of consensus on the definition for refractory uveitis, regardless of the treatment being used and revealed a new terminology based on a comprehensive and operational definition for each specific category of refractoriness.
Keywords
Adrenal Cortex Hormones/therapeutic use, Adult, Consensus, Humans, Immunomodulation, Inflammation/drug therapy, Treatment Outcome, Uveitis/diagnosis, Uveitis/drug therapy, Resistant, biologics, consensus, definition, glucocorticoids, immunomodulatory, intractable, refractory, uveitis treatment
Pubmed
Web of science
Create date
14/09/2020 13:11
Last modification date
18/11/2023 8:07
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