Article: article from journal or magazin.
Daptomycin for highly resistant Enterococcus faecium infection.
Swiss Medical Weekly
We report a case series of 11 patients with severe E. faecium infections treated with daptomycin. All strains were resistant to ampicillin (MIC >8 mg/l), but susceptible to vancomycin. Seven out of 11 strains were also highly resistant to gentamicin (MIC >500 mg/l). All patients were treated with multiple broad-spectrum antibiotics prior to isolation of E. faecium and had severe underlying diseases. Our experience suggests that salvage therapy with daptomycin might be a safe and efficacious treatment for E. faecium infections.
Aged, Aged, 80 and over, Anti-Bacterial Agents/pharmacology, Anti-Bacterial Agents/therapeutic use, Bacteremia/drug therapy, Daptomycin/pharmacology, Daptomycin/therapeutic use, Drug Resistance, Bacterial, Drug Therapy, Combination, Enterococcus faecium/drug effects, Enterococcus faecium/isolation & purification, Female, Humans, Male, Microbial Sensitivity Tests, Middle Aged
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