Courbe dose-reponse et etude clinique preliminaire d'un laxatif, le lactitol. [Dose-response curve and preliminary clinical study of a laxative, lactilol]
Details
Serval ID
serval:BIB_6C0253EDD8AB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Courbe dose-reponse et etude clinique preliminaire d'un laxatif, le lactitol. [Dose-response curve and preliminary clinical study of a laxative, lactilol]
Journal
Schweizerische Medizinische Wochenschrift
ISSN
0036-7672 (Print)
Publication state
Published
Issued date
12/1988
Volume
118
Number
50
Pages
1925-7
Notes
English Abstract
Journal Article --- Old month value: Dec 17
Journal Article --- Old month value: Dec 17
Abstract
15 women complaining of chronic constipation were included in a prospective open trial to determine the laxative action and minimal effective dose of lactitol. Through the administration of increasing doses, an ED50 of 0.25 g/kg/day, was established. During a 15-day treatment period at the minimal effective dose, all patients had reduced symptoms of constipation as compared with a previous 15-day control period. Side effects of minor intensity were frequently recorded (flatulence, rumblings, wind, and, less frequently, abdominal cramps or nausea). Thus, the use of lactitol for symptomatic treatment of constipation deserves further clinical studies to determine better its indications and benefit.
Keywords
Adult
Cathartics/adverse effects/*therapeutic use
Constipation/*drug therapy
Dose-Response Relationship, Drug
Female
Humans
Middle Aged
Sugar Alcohols/administration & dosage/adverse effects/*therapeutic use
Pubmed
Web of science
Create date
25/01/2008 11:40
Last modification date
20/08/2019 15:26