MR-IMPACT: comparison of perfusion-cardiac magnetic resonance with single-photon emission computed tomography for the detection of coronary artery disease in a multicentre, multivendor, randomized trial.

Détails

ID Serval
serval:BIB_6BF0C6CCE6C6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
MR-IMPACT: comparison of perfusion-cardiac magnetic resonance with single-photon emission computed tomography for the detection of coronary artery disease in a multicentre, multivendor, randomized trial.
Périodique
European Heart Journal
Auteur(s)
Schwitter J., Wacker C.M., van Rossum A.C., Lombardi M., Al-Saadi N., Ahlstrom H., Dill T., Larsson H.B., Flamm S.D., Marquardt M., Johansson L.
ISSN
0195-668X (Print)
ISSN-L
0195-668X
Statut éditorial
Publié
Date de publication
2008
Volume
29
Numéro
4
Pages
480-489
Langue
anglais
Notes
Publication types: Clinical Trial, Phase II ; Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
AIMS: To determine in a multicentre, multivendor trial the diagnostic performance for perfusion-cardiac magnetic resonance (perfusion-CMR) in comparison with coronary X-ray angiography (CXA) and single-photon emission computed tomography (SPECT).
METHODS AND RESULTS: Of 241 eligible patients from 18 centres, 234 were randomly dosed with 0.01, 0.025, 0.05, 0.075, or 0.1 mmol/kg Gd-DTPA-BMA (Omniscantrade mark, GE-Healthcare) per stress (0.42 mg/kg adenosine) and rest perfusion study. Coronary artery disease (CAD) was defined as diameter stenosis > or =50% on quantitative CXA. Five CMR and eight SPECT studies (of 225 complete studies) were excluded from analyses due to inadequate quality (three blinded readers scored per modality). The comparison of CMR vs. SPECT was based on receiver operating characteristic (ROC) analysis. Perfusion-CMR at the optimal CM dose (0.1 mmol/kg) had similar performance as SPECT, if only the SPECT studies of the 42 patients with this dose were considered [area under ROC curve (AUC): 0.86 +/- 0.06 vs. 0.75 +/- 0.09 for SPECT, P = 0.12]; however, diagnostic performance of perfusion-CMR was better vs. the entire SPECT population (AUC: 0.67 +/- 0.05, n = 212, P = 0.013).
CONCLUSIONS: In this multicentre, multivendor trial, ROC analyses suggest perfusion-CMR as a valuable alternative to SPECT for CAD detection showing equal performance in the head-to-head comparison. Comparing perfusion-CMR with the entire SPECT population suggests CMR superiority over SPECT, which warrants further evaluation in larger trials.
Mots-clé
Adult, Aged, Aged, 80 and over, Coronary Artery Disease/diagnosis, Coronary Artery Disease/radionuclide imaging, Epidemiologic Methods, Female, Humans, Magnetic Resonance Angiography/methods, Male, Middle Aged, Tomography, Emission-Computed, Single-Photon/methods
Pubmed
Web of science
Open Access
Oui
Création de la notice
07/09/2011 17:59
Dernière modification de la notice
20/08/2019 15:26
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