Dramatic dysbalancing of the Wnt pathway in breast cancers.

Détails

ID Serval
serval:BIB_6BEF7BCFE5BC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Dramatic dysbalancing of the Wnt pathway in breast cancers.
Périodique
Scientific reports
Auteur(s)
Koval A., Katanaev V.L.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
09/05/2018
Peer-reviewed
Oui
Volume
8
Numéro
1
Pages
7329
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Wnt signaling is important for breast development and remodeling during pregnancy and lactation. Epigenetic modifications change expression levels of components of the Wnt pathway, underlying oncogenic transformation. However, no clear Wnt component increasing expression universally across breast cancer (BC) or its most Wnt-dependent triple-negative BC (TNBC) subgroup has been identified, delaying development of targeted therapies. Here we perform network correlation analysis of expression of >100 Wnt pathway components in hundreds of healthy and cancerous breast tissues. Varying in expression levels among people, Wnt components remarkably coordinate their production; this coordination is dramatically decreased in BC. Clusters with coordinated gene expression exist within the healthy cohort, highlighting Wnt signaling subtypes. Different BC subgroups are identified, characterized by different remaining Wnt signaling signatures, providing the rational for patient stratification for personalizing the therapeutic applications. Key pairwise interactions within the Wnt pathway (some inherited and some established de novo) emerge as targets for future drug discovery against BC.
Mots-clé
Breast Neoplasms/genetics, Breast Neoplasms/metabolism, Breast Neoplasms/physiopathology, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cohort Studies, Female, Frizzled Receptors/genetics, Frizzled Receptors/metabolism, Humans, Triple Negative Breast Neoplasms/genetics, Triple Negative Breast Neoplasms/metabolism, Wnt Proteins/metabolism, Wnt Signaling Pathway/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/05/2018 18:48
Dernière modification de la notice
16/12/2019 6:19
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