Association between serum levels of reactive nitrogen intermediates and coma in children with cerebral malaria in Papua New Guinea

Details

Serval ID
serval:BIB_6B8B855BAFAA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association between serum levels of reactive nitrogen intermediates and coma in children with cerebral malaria in Papua New Guinea
Journal
Transactions of the Royal Society of Tropical Medicine and Hygiène
Author(s)
Al Yaman  F. M., Mokela  D., Genton  B., Rockett  K. A., Alpers  M. P., Clark  I. A.
ISSN
0035-9203 (Print)
Publication state
Published
Issued date
06/1996
Volume
90
Number
3
Pages
270-3
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May-Jun
Abstract
Serum levels of reactive nitrogen intermediates (RNI; nitrate plus nitrite) were measured in 92 patients with cerebral malaria in the Madang Province of Papua New Guinea. RNI levels were compared to disease severity and clinical outcome, and correlated with both the depth of coma on admission and its duration. Median levels were higher among children with deeper coma than among those with lighter coma (35.6 microM vs. 16.7 microM; P = 0.008) and also among children with longer duration of coma (72 h; 59.3 microM vs. 19.3 microM; P = 0.004). RNI levels also correlated with clinical outcome, fatal cases having significantly higher RNI levels than survivors (41.2 microM vs. 18.5 microM; P = 0.014). Thus, high RNI levels are associated with indices of disease severity and may predict outcome in children with cerebral malaria. These data are consistent with the hypothesis that nitric oxide is involved in the pathogenesis of coma in human cerebral malaria.
Keywords
Child Child, Preschool Coma/*blood/etiology Female Humans Hypoglycemia/complications Infant Malaria, Cerebral/*blood/complications Male Nitrates/*blood Nitrites/*blood Papua New Guinea Parasitemia/blood Severity of Illness Index Treatment Outcome
Pubmed
Web of science
Create date
28/01/2008 11:48
Last modification date
20/08/2019 14:25
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