Osmoregulation during Long-Term Fasting in Lungfish and Elephant Seal: Old and New Lessons for the Nephrologist.

Détails

ID Serval
serval:BIB_6B552774823B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Osmoregulation during Long-Term Fasting in Lungfish and Elephant Seal: Old and New Lessons for the Nephrologist.
Périodique
Nephron
Auteur(s)
Rossier B.C.
ISSN
2235-3186 (Electronic)
ISSN-L
1660-8151
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
134
Numéro
1
Pages
5-9
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Vertebrates control the osmolality of their extra- and intra-cellular compartments despite large variations in salt and water intake. Aldosterone-dependent sodium reabsorption and vasopressin-dependent water transport in the distal nephron and collecting duct play a critical role in the final control of sodium and water balance. Long-term fasting (no eating, no drinking) represents an osmotic challenge for survival. Evolution has found very different solutions to meet this challenge. To illustrate this point, I will discuss osmoregulation of a mammal (elephant seal pup) and of a fish (lungfish) that are able to survive long-term fasting for months or even years. Homer W. Smith taught us how informative comparative anatomy and physiology of the kidney could help physiologists and nephrologists to better understand how the kidney works. In recent years, comparative genomics, transcriptomics and proteomics across the tree of life have led to the emergence of a new discipline, evolutionary medicine. In the near future, physiologists and nephrologists will benefit from this new field of investigation, thanks to its potential for the identification of novel drug targets and therapies.

Mots-clé
Animals, Arginine Vasopressin/physiology, Biological Evolution, Fasting, Fishes/physiology, Osmoregulation, Renin-Angiotensin System, Seals, Earless/physiology
Pubmed
Open Access
Oui
Création de la notice
16/02/2016 17:31
Dernière modification de la notice
21/08/2019 5:33
Données d'usage