Clinical validity of delayed recall tests as a gateway biomarker for Alzheimer's disease in the context of a structured 5-phase development framework.

Details

Serval ID
serval:BIB_6B3D3B8E5C16
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Clinical validity of delayed recall tests as a gateway biomarker for Alzheimer's disease in the context of a structured 5-phase development framework.
Journal
Neurobiology of aging
Author(s)
Cerami C., Dubois B., Boccardi M., Monsch A.U., Demonet J.F., Cappa S.F.
Working group(s)
Geneva Task Force for the Roadmap of Alzheimer's Biomarkers
ISSN
1558-1497 (Electronic)
ISSN-L
0197-4580
Publication state
Published
Issued date
04/2017
Peer-reviewed
Oui
Volume
52
Pages
153-166
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Although Alzheimer's disease criteria promote the use of biomarkers, their maturity in clinical routine still needs to be assessed. In the light of the oncology framework, we conducted a literature review on measures used to assess delayed recall impairment due to medial temporal lobe dysfunction (i.e., free and cued word list recall tests). Ample evidence is available for phases 1 (rationale for use), 2 (discriminative ability), and 3 (early detection ability) for many of the tests in routine use. Evidence about phase 4 (performance in real world) and phase 5 (quantify impact and costs) is yet to come. Administration procedures have been standardized and cutoff scores are well validated in large Alzheimer's disease and mild cognitive impaired series. Some aspects (e.g., different task formats), however, hamper the comparability of results among different populations and the reproducibility between laboratories. No definite guideline for their use can thus be proposed at the moment. Accordingly, the maturity of such markers is not yet sufficient and requires future investigation to promote the proper use of memory measures in clinical settings.

Keywords
Alzheimer Disease/diagnosis, Alzheimer Disease/physiopathology, Alzheimer Disease/psychology, Biomarkers/analysis, Cognitive Dysfunction/diagnosis, Cognitive Dysfunction/psychology, Cues, Early Diagnosis, Humans, Memory, Episodic, Mental Recall, Neuropsychological Tests, Reproducibility of Results, Temporal Lobe/physiopathology, 5-Phases, Alzheimer's disease, Biomarker development, Biomarker-based diagnosis, Cued recall tasks, Delayed recall, Early diagnosis, Episodic memory, Free word list tests, Mild cognitive impairment
Pubmed
Web of science
Create date
28/03/2017 18:14
Last modification date
20/08/2019 15:25
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