Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies

Details

Serval ID
serval:BIB_6B2B665F8EC9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies
Journal
Nat Rev Nephrol
Author(s)
Zuber J., Fakhouri F., Roumenina L. T., Loirat C., Fremeaux-Bacchi V.
Working group(s)
French Study Group for a, Hus C. G.
ISSN
1759-507X (Electronic)
ISSN-L
1759-5061
Publication state
Published
Issued date
11/2012
Volume
8
Number
11
Pages
643-57
Language
english
Notes
Zuber, Julien
Fakhouri, Fadi
Roumenina, Lubka T
Loirat, Chantal
Fremeaux-Bacchi, Veronique
eng
Review
England
Nat Rev Nephrol. 2012 Nov;8(11):643-57. doi: 10.1038/nrneph.2012.214. Epub 2012 Oct 2.
Abstract
In the past decade, a large body of evidence has accumulated in support of the critical role of dysregulation of the alternative complement pathway in atypical haemolytic uraemic syndrome (aHUS) and C3 glomerulopathies. These findings have paved the way for innovative therapeutic strategies based on complement blockade, and eculizumab, a monoclonal antibody targeting the human complement component 5, is now widely used to treat aHUS. In this article, we review 28 case reports and preliminary data from 37 patients enrolled in prospective trials of eculizumab treatment for episodes of aHUS involving either native or transplanted kidneys. Eculizumab may be considered as an optimal first-line therapy when the diagnosis of aHUS is unequivocal and this treatment has the potential to rescue renal function when administered early after onset of the disease. However, a number of important issues require further study, including the appropriate duration of treatment according to an individual's genetic background and medical history, the optimal strategy to prevent post-transplantation recurrence of aHUS and a cost-efficacy analysis. Data regarding the efficacy of eculizumab in the control of C3 glomerulopathies are more limited and less clear, but several observations suggest that eculizumab may act on the most inflammatory forms of this disorder.
Keywords
Antibodies, Monoclonal, Humanized/administration & dosage/*therapeutic use, Atypical Hemolytic Uremic Syndrome, Complement Activation/drug effects, Glomerulonephritis, Hemolytic-Uremic Syndrome/*drug therapy/immunology/physiopathology/surgery, Humans, Kidney/drug effects/physiopathology, Kidney Transplantation, Meningitis, Meningococcal/complications/prevention & control, Secondary Prevention
Pubmed
Create date
01/03/2022 10:18
Last modification date
02/03/2022 6:36
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