Association study of 182 candidate genes in anorexia nervosa.

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Serval ID
serval:BIB_6B19414F0835
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association study of 182 candidate genes in anorexia nervosa.
Journal
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Author(s)
Pinheiro A.P., Bulik C.M., Thornton L.M., Sullivan P.F., Root T.L., Bloss C.S., Berrettini W.H., Schork N.J., Kaye W.H., Bergen A.W., Magistretti P., Brandt H., Crawford S., Crow S., Fichter M.M., Goldman D., Halmi K.A., Johnson C., Kaplan A.S., Keel P.K., Klump K.L., La Via M., Mitchell J.E., Strober M., Rotondo A., Treasure J., Woodside D.B.
ISSN
1552-485X[electronic], 1552-4841[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
153B
Number
5
Pages
1070-1080
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural Publication Status: ppublish
Abstract
We performed association studies with 5,151 SNPs that were judged as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN) based on location under reported linkage peaks, previous results in the literature (182 candidate genes), brain expression, biological plausibility, and estrogen responsivity. We employed a case-control design that tested each SNP individually as well as haplotypes derived from these SNPs in 1,085 case individuals with AN diagnoses and 677 control individuals. We also performed separate association analyses using three increasingly restrictive case definitions for AN: all individuals with any subtype of AN (All AN: n = 1,085); individuals with AN with no binge eating behavior (AN with No Binge Eating: n = 687); and individuals with the restricting subtype of AN (Restricting AN: n = 421). After accounting for multiple comparisons, there were no statistically significant associations for any individual SNP or haplotype block with any definition of illness. These results underscore the importance of large samples to yield appropriate power to detect genotypic differences in individuals with AN and also motivate complementary approaches involving Genome-Wide Association (GWA) studies, Copy Number Variation (CNV) analyses, sequencing-based rare variant discovery assays, and pathway-based analysis in order to make up for deficiencies in traditional candidate gene approaches to AN.
Keywords
Adolescent, Adult, Aged, Anorexia Nervosa/genetics, Bulimia/genetics, Female, Genetic Association Studies, Genetic Predisposition to Disease/genetics, Haplotypes/genetics, Humans, Middle Aged, Phenotype, Polymorphism, Single Nucleotide/genetics, Young Adult
Pubmed
Web of science
Create date
18/01/2011 10:44
Last modification date
20/08/2019 14:25
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