Diagnostic accuracy of ¹⁸F-FDG-PET and PET/CT in patients with Ewing sarcoma family tumours: a systematic review and a meta-analysis.

Details

Serval ID
serval:BIB_6B1626479426
Type
Article: article from journal or magazin.
Collection
Publications
Title
Diagnostic accuracy of ¹⁸F-FDG-PET and PET/CT in patients with Ewing sarcoma family tumours: a systematic review and a meta-analysis.
Journal
Skeletal radiology
Author(s)
Treglia G., Salsano M., Stefanelli A., Mattoli M.V., Giordano A., Bonomo L.
ISSN
1432-2161 (Electronic)
ISSN-L
0364-2348
Publication state
Published
Issued date
03/2012
Peer-reviewed
Oui
Volume
41
Number
3
Pages
249-256
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Review
Publication Status: ppublish
Abstract
To systematically review and meta-analyse literature data on the diagnostic performance of fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) in patients with Ewing sarcoma family tumours (ESFT).
PubMed/MEDLINE, Embase and Scopus databases were searched for articles that evaluated FDG-PET and PET/CT in patients with ESFT from inception to 31 May 2011. Studies that fulfilled the three following criteria were included in the systematic review: FDG-PET or PET/CT performed in patients with ESFT; articles about the diagnostic accuracy of FDG-PET and PET/CT; sample size of at least 10 patients with ESFT were included. Studies in which there were sufficient data to reassess sensitivity and specificity of FDG-PET or PET/CT in ESFT were included in the meta-analysis, excluding duplicate publications. Finally, pooled sensitivity, pooled specificity and area under the receiver operating characteristic (ROC) curve of FDG-PET or PET/CT in ESFT were calculated.
We found 13 studies comprising a total of 342 patients with ESFT. The main findings of the studies included are presented. The meta-analysis of five selected studies provided these results about FDG-PET and PET/CT in ESFT: pooled sensitivity: 96% (95% confidence interval [CI] 91-99%); pooled specificity: 92% (95% CI 87-96%); area under the ROC curve: 0.97.
With regard to the staging and restaging of patients with ESFT, the sensitivity, specificity and accuracy of FDG-PET and PET/CT are high; the combination of FDG-PET or PET/CT with conventional imaging is a valuable tool for the staging and restaging of ESFT and has a relevant impact on the treatment strategy plan.

Keywords
Bone Neoplasms/diagnosis, Bone Neoplasms/epidemiology, Fluorodeoxyglucose F18, Humans, Positron-Emission Tomography/statistics & numerical data, Prevalence, Radiopharmaceuticals, Reproducibility of Results, Sarcoma, Ewing/diagnosis, Sarcoma, Ewing/epidemiology, Sensitivity and Specificity, Subtraction Technique/statistics & numerical data, Tomography, X-Ray Computed/statistics & numerical data
Pubmed
Web of science
Create date
20/08/2017 21:11
Last modification date
20/08/2019 14:25
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