An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System.

Détails

ID Serval
serval:BIB_6B1231846FC6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System.
Périodique
Neuron
Auteur(s)
Di Donato V., De Santis F., Albadri S., Auer T.O., Duroure K., Charpentier M., Concordet J.P., Gebhardt C., Del Bene F.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
97
Numéro
5
Pages
1049-1062.e6
Langue
anglais
Résumé
A conserved organizational and functional principle of neural networks is the segregation of axon-dendritic synaptic connections into laminae. Here we report that targeting of synaptic laminae by retinal ganglion cell (RGC) arbors in the vertebrate visual system is regulated by a signaling system relying on target-derived Reelin and VLDLR/Dab1a on the projecting neurons. Furthermore, we find that Reelin is distributed as a gradient on the target tissue and stabilized by heparan sulfate proteoglycans (HSPGs) in the extracellular matrix (ECM). Through genetic manipulations, we show that this Reelin gradient is important for laminar targeting and that it is attractive for RGC axons. Finally, we suggest a comprehensive model of synaptic lamina formation in which attractive Reelin counter-balances repulsive Slit1, thereby guiding RGC axons toward single synaptic laminae. We establish a mechanism that may represent a general principle for neural network assembly in vertebrate species and across different brain areas.

Mots-clé
Reelin, axon guidance, concentration gradient, optic tectum, synaptic laminae, zebrafish
Pubmed
Web of science
Création de la notice
29/03/2018 7:52
Dernière modification de la notice
20/08/2019 14:25
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