Optimized synthesis of O-carboxymethyl-N,N,N-trimethyl chitosan.

Details

Serval ID
serval:BIB_6AF8DAC7398D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Optimized synthesis of O-carboxymethyl-N,N,N-trimethyl chitosan.
Journal
Carbohydrate Polymers
Author(s)
Patrulea V., Applegate L.A., Ostafe V., Jordan O., Borchard G.
ISSN
1879-1344 (Electronic)
ISSN-L
0144-8617
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
122
Pages
46-52
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
We present here the synthesis of a highly O-carboxymethylated chitosan derivative. First, an improved protocol for the two-step synthesis of N-trimethyl chitosan (TMC) from chitosan was developed, yielding a maximum degree of quaternization (DQ) of up to 46.6%. Successively, the chitosan derivative O-carboxymethyl-N-trimethyl chitosan (CMTMC) was synthesized from the TMC obtained by applying an optimized synthesis pathway. In contrast to previous reports, the optimized protocol was shown to yield very high rates (>85%) of O-carboxymethylation of CMTMC, as shown by (1)H NMR and heteronuclear single quantum correlation ((1)H-(13)C HSQC). Finally, in vitro cytocompatibility (viability >80%) of the polymer was demonstrated using human fibroblasts.
Pubmed
Web of science
Create date
18/05/2015 15:23
Last modification date
20/08/2019 14:25
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