Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy.

Details

Serval ID
serval:BIB_6AE7078E9B90
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy.
Journal
Journal of Infectious Diseases
Author(s)
Bochud P.Y., Hawn T.R., Siddiqui M.R., Saunderson P., Britton S., Abraham I., Argaw A.T., Janer M., Zhao L.P., Kaplan G., Aderem A.
ISSN
0022-1899
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
197
Number
2
Pages
253-261
Language
english
Abstract
BACKGROUND: Leprosy is characterized by a spectrum of clinical manifestations that depend on the type of immune response against the pathogen. Patients may undergo immunological changes known as "reactional states" (reversal reaction and erythema nodosum leprosum) that result in major clinical deterioration. The goal of the present study was to assess the effect of Toll-like receptor 2 (TLR2) polymorphisms on susceptibility to and clinical presentation of leprosy. METHODS: Three polymorphisms in TLR2 (597C-->T, 1350T-->C, and a microsatellite marker) were analyzed in 431 Ethiopian patients with leprosy and 187 control subjects. The polymorphism-associated risk of developing leprosy, lepromatous (vs. tuberculoid) leprosy, and leprosy reactions was assessed by multivariate logistic regression models. RESULTS: The microsatellite and the 597C-->T polymorphisms both influenced susceptibility to reversal reaction. Although the 597T allele had a protective effect (odds ratio [OR], 0.34 [95% confidence interval {CI}, 0.17-0.68]; P= .002 under the dominant model), homozygosity for the 280-bp allelic length of the microsatellite strongly increased the risk of reversal reaction (OR, 5.83 [95% CI, 1.98-17.15]; P= .001 under the recessive model). These associations were consistent among 3 different ethnic groups. CONCLUSIONS: These data suggest a significant role for TLR-2 in the occurrence of leprosy reversal reaction and provide new insights into the immunogenetics of the disease.
Keywords
Adolescent, Adult, Case-Control Studies, Child, Child, Preschool, Ethiopia, Female, Genetic Predisposition to Disease, Haplotypes, Humans, Infant, Infant, Newborn, Leprosy, Linkage Disequilibrium, Male, Microsatellite Repeats, Middle Aged, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Toll-Like Receptor 2
Pubmed
Web of science
Open Access
Yes
Create date
10/02/2009 12:25
Last modification date
20/08/2019 14:25
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