The Gut-Lung Axis in Respiratory Disease

Details

Serval ID
serval:BIB_6ACE19B4C144
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The Gut-Lung Axis in Respiratory Disease
Journal
Annals of the American Thoracic Society
Author(s)
Marsland B.J., Trompette A., Gollwitzer E.S.
ISSN
2325-6621 (Electronic)
ISSN-L
2325-6621
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
12 Suppl 2
Pages
S150-S156
Language
english
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Abstract
Host-microorganism interactions shape local cell functionality, immune responses, and can influence disease development. Evidence indicates that the impact of host-microbe interactions reaches far beyond the local environment, thus influencing responses in peripheral tissues. There is a vital cross-talk between the mucosal tissues of our body, as exemplified by intestinal complications during respiratory disease and vice versa. Although, mechanistically, this phenomenon remains poorly defined, the existence of the gut-lung axis and its implications in both health and disease could be profoundly important for both disease etiology and treatment. In this review, we highlight how changes in the intestinal microenvironment, with a particular focus on the intestinal microbiota, impact upon respiratory disease.
Keywords
Intestinal Mucosa/microbiology, Probiotics/therapeutic use, Respiratory Mucosa/microbiology, Respiratory Tract Diseases/drug therapy, Respiratory Tract Diseases/microbiology
Pubmed
Create date
11/10/2016 15:30
Last modification date
20/08/2019 14:25
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