Reduced frontal white matter volume in children with early onset of adrenarche.

Details

Serval ID
serval:BIB_6A9F5D48FBC3
Type
Article: article from journal or magazin.
Collection
Publications
Title
Reduced frontal white matter volume in children with early onset of adrenarche.
Journal
Psychoneuroendocrinology
Author(s)
Klauser P., Whittle S., Simmons J.G., Byrne M.L., Mundy L.K., Patton G.C., Fornito A., Allen N.B.
ISSN
1873-3360 (Electronic)
ISSN-L
0306-4530
Publication state
Published
Issued date
02/2015
Peer-reviewed
Oui
Volume
52
Pages
111-118
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
While there is growing evidence that puberty affects brain development, very little is known about the structural brain changes associated with dehydroepiandrosterone (DHEA), an adrenal hormone that exhibits dramatic increases during adrenarche, the earliest phase of puberty. Moreover, no research has investigated whether relatively early exposure to DHEA (i.e., early adrenarche) during this period is associated with differences in brain structure. We ran a whole-brain voxel-based morphometry analysis on T1-weighted magnetic resonance imaging brain scans to compare gray (GMV) and white matter volumes (WMV) between children experiencing relatively early (n=41) vs. relatively late (n=44) adrenarche. We also investigated the correlations between GMV or WMV and DHEA levels, and finally, tested for sex differences in group and correlation analyses. We observed reduced frontal WMV in a cluster located on the left corona radiata in children experiencing earlier adrenarche. In addition, WMV in this area was negatively correlated with DHEA levels. We did not observe any effect of gender in both the group and the correlation analyses. Early onset of adrenarche (as defined by relatively early exposure to DHEA) may be associated with differences in the development of frontal white matter tracts.
Keywords
Adrenarche/metabolism, Adrenarche/physiology, Age Factors, Child, Dehydroepiandrosterone/analysis, Female, Frontal Lobe/growth & development, Gray Matter/growth & development, Humans, Magnetic Resonance Imaging, Male, White Matter/growth & development, Adolescence, Adrenarche, Brain, Childhood, Dehydroepiandrosterone, Gray matter, Magnetic resonance imaging, Puberty, Voxel-based morphometry, White matter
Pubmed
Web of science
Create date
07/02/2019 9:28
Last modification date
02/09/2019 5:26
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