Self-esteem, general self-efficacy and career adaptability, that includes career concern, control, curiosity and confidence, are important resources for adolescents who are required to make important educational and professional choices. No studies have investigated how these resources co-develop over time, and their impact on life satisfaction. In order to study more precisely this co-development and the impact of these resources on well-being, 357 Swiss adolescents were assessed three times during the last 17 months of compulsory school. The results showed an interrelationship between career adaptability and self-efficacy and a unidirectional effect of self-esteem on life satisfaction over time. They also highlighted the importance of career adapt-ability concern in predicting the other three career adapt-abilities. Overall, the results suggested that, in adolescents, higher levels of career adaptability may favor higher levels of general self-efficacy and that higher levels of self-esteem may induce higher levels of life satisfaction. Implications for practice are discussed.