Mitochondrial dysfunction in Autism Spectrum Disorder: clinical features and perspectives.
Details
Serval ID
serval:BIB_6A0E4C0FDC50
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Mitochondrial dysfunction in Autism Spectrum Disorder: clinical features and perspectives.
Journal
Current opinion in neurobiology
ISSN
1873-6882 (Electronic)
ISSN-L
0959-4388
Publication state
Published
Issued date
08/2017
Peer-reviewed
Oui
Volume
45
Pages
178-187
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Autism Spectrum Disorder (ASD) is a prototypic pervasive developmental disorder characterized by social interaction, and communication deficits, repetitive, stereotypic patterns of behavior, and impairments in language and development. Clinical studies have identified mitochondrial disturbances at the levels of DNA, activity, complexes, oxidative stress, and metabolites in blood and urine of ASD patients. However, these observations from postmortem brains or peripheral tissues do not provide a direct link between autism and mitochondria. The synaptic abnormality of autistic patients has not been investigated yet. Here we review the findings of clinical studies investigating mitochondrial involvement in ASD patients, focusing particularly on the brain and the limitations and future directions needed in order to fully understand the role of mitochondria in ASD pathology.
Pubmed
Web of science
Create date
26/06/2017 8:16
Last modification date
20/08/2019 14:24