Identification of novel elements of the Drosophila blisterome sheds light on potential pathological mechanisms of several human diseases.

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Ressource 1Télécharger: BIB_6A02E7B4E365.P001.pdf (2331.45 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_6A02E7B4E365
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Identification of novel elements of the Drosophila blisterome sheds light on potential pathological mechanisms of several human diseases.
Périodique
Plos One
Auteur(s)
Bilousov O., Koval A., Keshelava A., Katanaev V.L.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
9
Numéro
6
Pages
e101133
Langue
anglais
Notes
Publication types: Journal Article Publication Status: epublish
Résumé
Main developmental programs are highly conserved among species of the animal kingdom. Improper execution of these programs often leads to progression of various diseases and disorders. Here we focused on Drosophila wing tissue morphogenesis, a fairly complex developmental program, one of the steps of which - apposition of the dorsal and ventral wing sheets during metamorphosis - is mediated by integrins. Disruption of this apposition leads to wing blistering which serves as an easily screenable phenotype for components regulating this process. By means of RNAi-silencing technique and the blister phenotype as readout, we identify numerous novel proteins potentially involved in wing sheet adhesion. Remarkably, our results reveal not only participants of the integrin-mediated machinery, but also components of other cellular processes, e.g. cell cycle, RNA splicing, and vesicular trafficking. With the use of bioinformatics tools, these data are assembled into a large blisterome network. Analysis of human orthologues of the Drosophila blisterome components shows that many disease-related genes may contribute to cell adhesion implementation, providing hints on possible mechanisms of these human pathologies.
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/08/2014 17:45
Dernière modification de la notice
20/08/2019 14:24
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