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BBG2Na an RSV subunit vaccine candidate intramuscularly injected to human confers protection against viral challenge after nasal immunization in mice
Journal Article --- Old month value: Jul 16
Respiratory syncytial virus (RSV) is a major respiratory pathogen responsible for severe pulmonary disease. We have developed a parenterally administered vaccine, BBG2Na, which is currently in a phase III clinical trial. BBG2Na comprises residues 130--230 of RSV-A G protein (G2Na) fused to the BB carrier protein. In this study, we show that BBG2Na can be delivered by the nasal route and generates both mucosal and systemic antibody responses when co-administered with cholera toxin B or a newly described delivery system, zwittergent 3--14. We found that nasal BBG2Na administration protects against RSV challenge and does not induce lung immunopathology upon subsequent RSV challenge.
Administration, Intranasal Animals Antibodies, Viral/biosynthesis Cholera Toxin/administration & dosage Female HN Protein/immunology Humans Immunity, Mucosal Injections, Intramuscular Mice Mice, Inbred BALB C Nasal Mucosa/drug effects/pathology Quaternary Ammonium Compounds/administration & dosage/toxicity Respiratory Syncytial Virus Vaccines/*administration & dosage Respiratory Syncytial Viruses/*immunology Vaccines, Subunit/administration & dosage Viral Envelope Proteins
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