Predictive factors of unexpected lymphatic drainage pathways in early-stage cervical cancer.

Détails

ID Serval
serval:BIB_691F9C565A2D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Predictive factors of unexpected lymphatic drainage pathways in early-stage cervical cancer.
Périodique
Gynecologic oncology
Auteur(s)
Balaya V., Mathevet P., Magaud L., Bonsang-Kitzis H., Delomenie M., Montero Macias R., Ngô C., Bats A.S., Lécuru F.
ISSN
1095-6859 (Electronic)
ISSN-L
0090-8258
Statut éditorial
Publié
Date de publication
07/2019
Peer-reviewed
Oui
Volume
154
Numéro
1
Pages
102-109
Langue
anglais
Notes
Publication types: Journal Article

Résumé
The purpose of this study was to describe sentinel lymph nodes (SLN) topography in patients with early-stage cervical cancer and to determine factors associated with atypical lymphatic drainage pathway (LDP).
We analyzed the data of two prospective multicentric trials on SLN biopsy for cervical cancer (SENTICOL I and II) in women undergoing surgery for early-stage cervical cancer. SLN detection was realized with a combined labeling technique (Patent blue and radioactive tracer). Patients having bilateral SLN detection were included. Univariate and Multivariate analysis were performed by patients and by side to assess clinical and pathologic factors that may predict atypical LDP.
Between January 2005 and July 2012, 326 patients with 1104 intraoperative detected SLNs fulfilled the inclusion criteria. The SLNs were mainly located in the interiliac or external iliac area in 83.2%. The other localizations were: 9.2% in the common iliac area, 3.9% in the parametrium, 1.6% in the promontory area, 1.5% in the paraaortic area and 0.5% in other areas. Thirty-five patients (10.7%) had atypical SLN without SLN in typical area on one or both sides. In multivariate analysis, tumor size ≥20 mm appeared as an independent factor of having at least one exclusive atypical LDP (ORa = 3.95 95%CI = [1.60-9.78], p = 0.003). Multiparity decreased significantly the probability of having at least one exclusive atypical LDP (ORa = 0.16 95%CI = [0.07-0.39], p < 0.0001).
Tumor size larger than 20 mm and nulliparity increase the risk of having exclusive atypical LDP in early-stage cervical cancer.
Mots-clé
Cervical cancer, Lymphatic drainage, Radical hysterectomy, SENTICOL, Sentinel lymph node
Pubmed
Création de la notice
05/05/2019 14:25
Dernière modification de la notice
11/09/2019 5:26
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