The proteolytic activity of the paracaspase MALT1 is key in T cell activation

Details

Serval ID
serval:BIB_68ADE902DD96
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The proteolytic activity of the paracaspase MALT1 is key in T cell activation
Journal
Nature Immunology
Author(s)
Rebeaud F., Hailfinger S., Posevitz-Fejfar A., Tapernoux M., Moser R., Rueda D., Gaide O., Guzzardi M., Iancu E. M., Rufer N., Fasel N., Thome M.
ISSN
1529-2916
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
9
Number
3
Pages
272-281
Language
english
Abstract
The paracaspase MALT1 is pivotal in antigen receptor-mediated lymphocyte activation and lymphomagenesis. MALT1 contains a caspase-like domain, but it is unknown whether this domain is proteolytically active. Here we report that MALT1 had arginine-directed proteolytic activity that was activated after T cell stimulation, and we identify the signaling protein Bcl-10 as a MALT1 substrate. Processing of Bcl-10 after Arg228 was required for T cell receptor-induced cell adhesion to fibronectin. In contrast, MALT1 activity but not Bcl-10 cleavage was essential for optimal activation of transcription factor NF-kappaB and production of interleukin 2. Thus, the proteolytic activity of MALT1 is central to T cell activation, which suggests a possible target for the development of immunomodulatory or anticancer drugs
Keywords
Adaptor Proteins,Signal Transducing , Biochemistry , Caspases , Cell Adhesion , Cell Line , Electrophoresis,Gel,Two-Dimensional , Humans , immunology , Jurkat Cells , Lymphocyte Activation , metabolism , Neoplasm Proteins , NF-kappa B , Peptide Hydrolases , physiology , Protein Isoforms , Proteins , Switzerland , T-Lymphocytes
Pubmed
Web of science
Create date
29/01/2009 22:14
Last modification date
20/08/2019 14:23
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