Measurement of pancreatic stone protein in the identification and management of sepsis.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_6894DEBEEC4E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Measurement of pancreatic stone protein in the identification and management of sepsis.
Périodique
Biomarkers in medicine
Auteur(s)
Eggimann P., Que Y.A., Rebeaud F.
ISSN
1752-0371 (Electronic)
ISSN-L
1752-0363
Statut éditorial
Publié
Date de publication
02/2019
Peer-reviewed
Oui
Volume
13
Numéro
2
Pages
135-145
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Sepsis is a life-threatening syndrome characterized by a dysregulated host response to an infection resulting in multiple organ dysfunctions. Early diagnosis and management of sepsis is key to improve patient outcome but remains challenging. Despite extensive research, only few biomarkers have so far proven to be helpful in the diagnosis of sepsis. A novel protein biomarker, the pancreatic stone protein (PSP), is showing great promises. Several lines of evidences suggest that PSP has a higher diagnostic performance for the identification of sepsis than procalcitonin and C-reactive protein, and a strong prognostic value to predict unfavorable outcome at admission to intensive care unit. This review summarizes the current knowledge on the molecular mechanisms of PSP function and the clinical evidences available to highlight the relevance of this protein in the diagnosis and prognosis of sepsis.
Mots-clé
PSP, diagnosis, diagnostics, infection, prognosis, sepsis
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/02/2019 15:12
Dernière modification de la notice
20/08/2019 14:23
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