Menopausal Hormone Therapy Is Associated With Reduced Total and Visceral Adiposity: The OsteoLaus Cohort.

Détails

Ressource 1Télécharger: 29596606AM.pdf (579.26 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_688BCFC3131F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Menopausal Hormone Therapy Is Associated With Reduced Total and Visceral Adiposity: The OsteoLaus Cohort.
Périodique
The Journal of clinical endocrinology and metabolism
Auteur(s)
Papadakis G.E., Hans D., Rodriguez E.G., Vollenweider P., Waeber G., Marques-Vidal P., Lamy O.
ISSN
1945-7197 (Electronic)
ISSN-L
0021-972X
Statut éditorial
Publié
Date de publication
01/05/2018
Peer-reviewed
Oui
Volume
103
Numéro
5
Pages
1948-1957
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
After menopause, fat mass (FM) and visceral adipose tissue (VAT) increase and nonbone lean body mass (LBM) decreases. Whether menopausal hormone therapy (MHT) reverses these changes remains controversial.
To assess the effect of MHT on FM, VAT, and LBM before and after its withdrawal and evaluate potential confounders.
Cross-sectional study.
General community.
Women of the OsteoLaus cohort (50 to 80 years old) who underwent dual-energy X-ray absorptiometry (DXA) with body composition assessment. After we excluded women with estrogen-modifying medications, the 1053 participants were categorized into current users (CUs), past users (PUs), and never users (NUs) of MHT.
None.
VAT measured by DXA was the primary outcome. We assessed subtotal and android FM, LBM, muscle strength (hand grip), and confounding factors (caloric intake, physical activity, biomarkers).
The groups significantly differed in age, NU < CU < PU. Age-adjusted VAT was lower in CUs than NUs (P = 0.03). CUs exhibited lower age-adjusted body mass index (BMI) (-0.9 kg/m2) and a trend for lower FM (-1.3 kg). The 10-year gain of VAT (P < 0.01) and subtotal and android FM (P < 0.05) was prevented in CUs. No difference in LBM or hand grip was detected. No residual effect was detected for PUs, including for early MHT discontinuers. The confounding factors did not significantly differ between groups except for higher caloric intake in PUs compared with NUs.
MHT is associated with significantly decreased VAT, BMI, and android FM. No benefit is detected for LBM. The benefits are not preserved in PUs, suggesting caution when MHT is discontinued.
Mots-clé
Adiposity/drug effects, Aged, Aged, 80 and over, Body Composition/drug effects, Bone Density/drug effects, Cohort Studies, Cross-Sectional Studies, Down-Regulation/drug effects, Estrogen Replacement Therapy/statistics & numerical data, Estrogens/pharmacology, Estrogens/therapeutic use, Female, Hand Strength, Humans, Intra-Abdominal Fat/drug effects, Middle Aged, Obesity, Abdominal/epidemiology, Obesity, Abdominal/prevention & control
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/04/2018 17:49
Dernière modification de la notice
20/08/2019 14:23
Données d'usage