Article: article from journal or magazin.
Prior contacts with the 2000-2003 seasonal vaccines extends the 2009 pandemic A/H1N1 vaccine-specific immune protection to non-humoral compartments
European Geriatric Medicine
Activating different adaptive immune component is required to confer long-time protection against influenza viruses. By investigating the co-mobilization of immune compartments following A/H1N1 2009 pandemic vaccine (A(H1N1)pdm09 influenza vaccine-Panenza(R), Sanofi Pasteur), we show that multiple vaccination with 2000-2003 seasonal influenza vaccines leads to a broader immune repertoire than the one theoretically expected by vaccine strains. Moreover, in case of contact with strains previously encountered, the A(H1N1)pdm09-specific immune response is extended to non-humoral immune components (i.e. CD8+ and/or CD4+ T-cells response).
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