Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Eosinophilic aseptic arachnoiditis. A neurological complication in HIV-negative drug-addicts.
Journal of neurology
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
The finding of an eosinophilic aseptic meningitis in IV drug abuse is usually suggestive of an opportunistic infection or an allergic reaction. However, HIV-negative patients are at lower risk for developing these complications. Two young HIV-negative patients, with previous intravenous polytoxicomany, developed cystic arachnoiditis over the spinal cord associated with eosinophilic meningitis. Histology of the meningeal spinal cord lesions revealed a vasculocentric mixed inflammatory reaction. In one patient prednisone led to marked clinical improvement. Since infection, vasculitis, sarcoidosis and previous myelography were ruled out, we believe that the syndrome of eosinophilic aseptic arachnoiditis may be related to an hyperergic reaction in the meniges toward drug-adulterants inoculated through the intravenous route.
Adult, Anti-Inflammatory Agents, Arachnoiditis, Eosinophilia, Female, Humans, Male, Prednisone, Substance Abuse, Intravenous, Syndrome, Treatment Outcome
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