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TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1.
Trends in Immunology
T-cell receptor (TCR) engagement induces the maturation of thymocytes and the activation and proliferation of peripheral T cells through signaling pathways that target several transcription factors. The transcription factor nuclear factor-κB (NF-κB) has an essential role in the activation of mature T cells but the signaling pathway leading from TCR stimulation to NF-κB activation is not well defined. Carma1, Bcl10 and MALT1 are recently identified proteins that have an important and previously unexpected role in antigen receptor-induced NF-κB activation and the control of lymphocyte proliferation. We believe that the recent advances in this field could stimulate research for the development of new immunomodulatory drugs and could lead to a better understanding of the molecular mechanisms underlying the formation of lymphomas and potentially of other immune disorders.
Adaptor Proteins, Signal Transducing, Animals, Caspases, Guanylate Kinase, Humans, Lymphocyte Activation, Lymphoma, B-Cell, Marginal Zone/chemistry, Lymphoma, B-Cell, Marginal Zone/immunology, NF-kappa B/immunology, NF-kappa B/metabolism, Neoplasm Proteins/chemistry, Neoplasm Proteins/immunology, Nucleoside-Phosphate Kinase/immunology, Nucleoside-Phosphate Kinase/metabolism, Receptors, Antigen, T-Cell/immunology, Receptors, Antigen, T-Cell/metabolism, Signal Transduction
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