Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions.
Details
Serval ID
serval:BIB_67C40EE6710B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions.
Journal
Science advances
ISSN
2375-2548 (Electronic)
ISSN-L
2375-2548
Publication state
Published
Issued date
27/10/2023
Peer-reviewed
Oui
Volume
9
Number
43
Pages
eadg6874
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Interleukins are secreted proteins that regulate immune responses. Among these, the interleukin 12 (IL-12) family holds a central position in inflammatory and infectious diseases. Each family member consists of an α and a β subunit that together form a composite cytokine. Within the IL-12 family, IL-35 remains particularly ill-characterized on a molecular level despite its key role in autoimmune diseases and cancer. Here we show that both IL-35 subunits, IL-12α and EBI3, mutually promote their secretion from cells but are not necessarily secreted as a heterodimer. Our data demonstrate that IL-12α and EBI3 are stable proteins in isolation that act as anti-inflammatory molecules. Both reduce secretion of proinflammatory cytokines and induce the development of regulatory T cells. Together, our study reveals IL-12α and EBI3, the subunits of IL-35, to be functionally active anti-inflammatory immune molecules on their own. This extends our understanding of the human cytokine repertoire as a basis for immunotherapeutic approaches.
Keywords
Humans, Cytokines/metabolism, Interleukin-12/metabolism, Interleukins/metabolism, Minor Histocompatibility Antigens/metabolism, T-Lymphocytes, Regulatory
Pubmed
Open Access
Yes
Create date
26/10/2023 13:59
Last modification date
08/08/2024 6:26