Farming amphetamines: Khat (Catha edulis Forsk) a traditional plant with psychoactive and medicinal properties

Détails

ID Serval
serval:BIB_67BBDB9E4CB5
Type
Partie de livre
Sous-type
Chapitre: chapitre ou section
Collection
Publications
Titre
Farming amphetamines: Khat (Catha edulis Forsk) a traditional plant with psychoactive and medicinal properties
Titre du livre
Medicinal and Aromatic Plants of the Middle-East
Auteur(s)
Ben Shabat S., Goloubinoff P., Dudai N., Lewinsohn E.
Editeur
Springer
ISBN
978-94-017-9275-2
Statut éditorial
Publié
Date de publication
2015
Editeur scientifique
Zohara  Y, Dudai N.
Volume
2
Série
Medicinal and Aromatic Plants of the World
Numéro de chapitre
9
Pages
181-198
Langue
anglais
Résumé
Khat (Catha edulis Forsk., Celastraceae) is a flowering perennial shrub with a long history of use and cultivation in East Africa and the Arabian Peninsula. Young khat leaves are traditionally chewed in social gatherings to attain special states of mind, aimed especially at awakeness and enhanced mind focus. Since khat chewing contains amphetamine-like molecules and reponedly causes addiction among users it is banned in most countries, but it is part of social life and legal in some countries. The main phannacoactive compounds present in khat leaves are the phenylpropylamino alkaloids (S) cathinone and (S)-cathine. L-Phenylalan:ine serves as a key biosynthetic precursor of phenylpropylalkaloids. Phenylalanine is converted by a series of not yet fully characterized reactions involving chain-shortening to benzaldehyde, then ligation to decarboxylated pyruvate, oxidation and incorporation of an amino group to yield (S)-cath inone, the most active compound accumulating in young leaves. (S)-Cathinone is subsequently reduced to (S)-cathine, the main compound accumulated in mature leaves, but pharmacologically less active than (S)-cathinone. The pharmacological prospects of khat uses and some personal experiences of one of the authors in khat chewing are described here.
Mots-clé
Khat, Catha edulis, Celastraceae, cathinone, phenylpropylamino alkaloids, amphetamines
Création de la notice
28/07/2014 11:04
Dernière modification de la notice
20/08/2019 15:23
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