Complications neuro-ophtalmologiques du lupus erythemateux dissemine. [Neuro-ophthalmologic complications of disseminated lupus erythematosus]

Détails

ID Serval
serval:BIB_67B7EFE86C91
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Complications neuro-ophtalmologiques du lupus erythemateux dissemine. [Neuro-ophthalmologic complications of disseminated lupus erythematosus]
Périodique
Klinische Monatsblatter fur Augenheilkunde
Auteur(s)
Borruat  F. X., Prado  T., Strominger  M., Schatz  N. J., Glaser  J. S.
ISSN
0023-2165 (Print)
Statut éditorial
Publié
Date de publication
05/1994
Volume
204
Numéro
5
Pages
403-6
Notes
Case Reports
English Abstract
Journal Article --- Old month value: May
Résumé
BACKGROUND: Systemic lupus erythematosus (SLE) is a multisystemic inflammatory disease of unknown etiology. Physiopathology includes small vessel occlusion and auto-antibody production. Neuro-ophthalmic complications can be detected in 10-30% of SLE cases. Further, some patients can present with neuro-ophthalmic complications prior to diagnosis of SLE. PATIENTS AND METHODS: We report seven cases of neuro-ophthalmic complications of SLE demonstrating lesions from the retina to the brain. The other possible manifestations of SLE will be reviewed. RESULTS: Two cases were not yet diagnosed with SLE when neuro-ophthalmic disease occurred. Anti-double stranded DNA antibodies were detected at a very high titer, suggesting SLE, later confirmed by rheumatologists. CONCLUSIONS: Ophthalmologists should be aware of the unusual patient presenting with a neuroophthalmic disorder prior to the diagnosis of SLE. In such cases, autoantibodies should be sought. Antinuclear antibodies are very sensitive but non specific for SLE. Anti-double stranded DNA antibodies are specific for SLE and elevated titer should raise the suspicion of undiagnosed SLE.
Mots-clé
Adult Antibodies, Antinuclear/analysis Female Fluorescein Angiography Humans Lupus Erythematosus, Systemic/*diagnosis/immunology Magnetic Resonance Imaging Male Middle Aged Optic Nerve Diseases/*diagnosis/immunology Retinal Diseases/*diagnosis/immunology Vision, Low/*diagnosis/immunology
Pubmed
Web of science
Création de la notice
28/01/2008 12:37
Dernière modification de la notice
20/08/2019 14:23
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