Occurrence and prognosis of lymph node metastases in patients selected for isolated limb perfusion with soft tissue sarcoma.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC 4.0
ID Serval
serval:BIB_6786C75D78F3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Occurrence and prognosis of lymph node metastases in patients selected for isolated limb perfusion with soft tissue sarcoma.
Périodique
Journal of Cancer
Auteur(s)
Crettenand F., Martin D., Cherix S., Demartines N., Matter M.
ISSN
1837-9664 (Print)
ISSN-L
1837-9664
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
9
Numéro
18
Pages
3311-3315
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
<b>
<i>Background and Objectives:</i>
</b> Extensive surgery is often required for advanced soft tissue sarcoma (STS) of the limb. In the 1980s, a new approach was developed: isolated limb perfusion (ILP). This study aimed to assess incidence and impact on patient survival based on lymph node metastasis with systematic radical lymphadenectomy during ILP. <b>
<i>Methods:</i>
</b> Retrospective study of 57 consecutive patients treated by ILP for limb STS with simultaneous radical lymph node dissection in our tertiary referral center between 1992 and 2015. <b>
<i>Results:</i>
</b> Median age was 62 years (19-87) and 30 patients were male (53%). Lymph node involvement was observed in 13 patients (N1, 23%), regarded as metastatic spreading in 4 angiosarcomas, 3 epithelioid sarcomas, 2 leiomyosarcomas, 2 undifferentiated sarcomas and 2 synovial sarcomas. For the N0 patient group, median survival was 73.9 months (CI 95% 41.9-105.9) compared to 15.1 months (CI 95% 7.4-22.6) in case of metastatic lymph node ( <i>p</i> =0.002). The median disease-free survival was 33,0 months (CI 95% 12,5-53.5) in N0 group and 8.0 months (CI 95% 4.0-11.9) in N1 ( <i>p</i> =0.006). <b>
<i>Conclusions:</i>
</b> Lymph node metastases of STS patients selected for ILP seemed to have a negative impact on both overall and disease-free survival. Radical lymph node dissection should be included in ILP procedure.
Mots-clé
incidence, limb sarcoma, lymph node metastases, prognosis
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/10/2018 16:59
Dernière modification de la notice
20/08/2019 14:23
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