Peroxisome proliferator-activated receptor beta/delta as a therapeutic target for metabolic diseases.

Details

Serval ID
serval:BIB_67776232E1A7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Peroxisome proliferator-activated receptor beta/delta as a therapeutic target for metabolic diseases.
Journal
Expert Opinion On Therapeutic Targets
Author(s)
Bedu E., Wahli W., Desvergne B.
ISSN
1744-7631 (Electronic)
ISSN-L
1472-8222
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
9
Number
4
Pages
861-873
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The peroxisome proliferator-activated receptor (PPAR) family comprises three distinct isotypes: PPARalpha, PPARbeta/delta and PPARgamma. PPARs are nuclear hormone receptors that mediate the effects of fatty acids and their derivatives at the transcriptional level. Until recently, the characterisation of the important role of PPARalpha in fatty acid oxidation and of PPARgamma in lipid storage contrasted with the sparse information concerning PPARbeta/delta. However, evidence is now emerging for a role of PPARbeta/delta in tissue repair and energy homeostasis. Experiments with tissue-specific overexpression of PPARbeta/delta or treatment of mice with selective PPARbeta/delta agonists demonstrated that activation of PPARbeta/delta in vivo increases lipid catabolism in skeletal muscle, heart and adipose tissue and improves the serum lipid profile and insulin sensitivity in several animal models. PPARbeta/delta activation also prevents the development of obesity and improves cholesterol homeostasis in obesity-prone mouse models. These new insights into PPARbeta/delta functions suggest that targeting PPARbeta/delta may be helpful for treating disorders associated with the metabolic syndrome. Although these perspectives are promising, several independent and contradictory reports raise concerns about the safety of PPARbeta/delta ligands with respect to tumourigenic activity in the gut. Thus, it appears that further exploration of PPARbeta/delta functions is necessary to better define its potential as a therapeutic target.
Keywords
Animals, Gene Expression Regulation, Humans, Metabolic Diseases/drug therapy, Metabolic Diseases/metabolism, PPAR delta/antagonists & inhibitors, PPAR delta/genetics, PPAR-beta/antagonists & inhibitors, PPAR-beta/genetics
Pubmed
Web of science
Create date
24/01/2008 16:26
Last modification date
20/08/2019 15:23
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