Geographic variation in the frequency of isolation and fluconazole and voriconazole susceptibilities of Candida glabrata: an assessment from the ARTEMIS DISK Global Antifungal Surveillance Program.

Pfaller, M.A.; Diekema, D.J.; Gibbs, D.L.; Newell, V.A.; Barton, R.; Bijie, H.; Bille, J.; Chang, S.C.; da Luz Martins, M.; Duse, A.; Dzierzanowska, D.; Ellis, D.; Finquelievich, J.; Gould, I.; Gur, D.; Hoosen, A.; Lee, K.; Mallatova, N.; Mallie, M.; Peng, N.G.; Petrikos, G.; Santiago, A.; Trupl, J.; VanDen Abeele, A.M.; Wadula, J.; Zaidi, M.

doi:10.1016/j.diagmicrobio.2010.01.002

Geographic variation in the frequency of isolation and fluconazole and voriconazole susceptibilities of Candida glabrata: an assessment from the ARTEMIS DISK Global Antifungal Surveillance Program.

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Serval ID

serval:BIB_677592ECADCF

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Geographic variation in the frequency of isolation and fluconazole and voriconazole susceptibilities of Candida glabrata: an assessment from the ARTEMIS DISK Global Antifungal Surveillance Program.

Journal

Diagnostic Microbiology and Infectious Disease

Author(s)

Pfaller M.A., Diekema D.J., Gibbs D.L., Newell V.A., Barton R., Bijie H., Bille J., Chang S.C., da Luz Martins M., Duse A., Dzierzanowska D., Ellis D., Finquelievich J., Gould I., Gur D., Hoosen A., Lee K., Mallatova N., Mallie M., Peng N.G., Petrikos G., Santiago A., Trupl J., VanDen Abeele A.M., Wadula J., Zaidi M.

Working group(s)

Global Antifungal Surveillance Group

Contributor(s)

Tiraboschi IN., Finquelievich J., Ellis D., Chen S., Halliday C., Pasqualotto AC., Colombo AL., Martino MD., Hoban D., Rennie R., Sanche S., Guzman AM., Wang F., Bijie H., Zhong N., Xu Y., Yu Y., de Bedout C., Restrepo A., del Pilar Rivas J., Quevedo R., Mendez M., Mallatova N., Dobiasova S., Zurita J., Ayabaca J., Koukila-Kähkölä P., Cassaing S., Nagy E., Nikolova R., Keller N., D'Antonio D., Manno G., Fortina G., Andreoni S., Raponi G., Ghezzi MC., Testore GP., Schito G., Soro O., Scalise G., Martino P., Tullio V., Lee K., Yong D., Lee MK., Kim MN., Peng NK., Noriega ER., Morfín R., Santos JI., Alpuche-Aranda CM., Zaidi M., Meis JF., Dzierzanowska D., Garczewska B., Szygula U., Amorim J., Lopes V., Da Fonseca JC. , Albuquerque L., Alves AF., da Luz Martins M., Jorge R., Rosado L., Verissímo C., Velho R., Kliasova G., Dmitrieva NV., Vaculikova A., Trupl J., Hupkova H., Fandakova I., Lisalova M., Duse A., Hoosen A., Crewe-Brown HH., Roditi D., van Rensburg MN. , Wende L., del Palacio A., Canton R., Yu KW., Wang JH., Vorachit M., Gur D., Korten V., Mulazimoglu L., Gould I., Weightman N., Galloway A., Herring A., Segal B., Suh B., Kauffman C., Bruckner D., Horn D., Larone D., Sussland D., Hardy DJ., Baron EJ., Doern G., Hall GS., Nguyen H., Rankin I., Jorgensen J., Thompson J., DiPersio JR., Vazquez J., Dolan J., Carroll K., Van Horn K., Hazen K., Steele-Moore L., Ghannoum M., Appelbaum P., Shoham S., Davis T., Chaturvedi V., Nolte R., Stockton M., Santiago A., Guzman M., Reyes H.

ISSN

1879-0070 (Electronic)

ISSN-L

0732-8893

Publication state

Published

Issued date

2010

Volume

Number

Pages

162-171

Language

english

Notes

Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Abstract

Geographic differences in frequency and azole resistance among Candida glabrata may impact empiric antifungal therapy choice. We examined geographic variation in isolation and azole susceptibility of C. glabrata. We examined 23 305 clinical isolates of C. glabrata during ARTEMIS DISK global surveillance. Susceptibility testing to fluconazole and voriconazole was assessed by disk diffusion, and the results were grouped by geographic location: North America (NA) (2470 isolates), Latin America (LA) (2039), Europe (EU) (12 439), Africa and the Middle East (AME) (728), and Asia-Pacific (AP) (5629). Overall, C. glabrata accounted for 11.6% of 201 653 isolates of Candida and varied as a proportion of all Candida isolated from 7.4% in LA to 21.1% in NA. Decreased susceptibility (S) to fluconazole was observed in all geographic regions and ranged from 62.8% in AME to 76.7% in LA. Variation in fluconazole susceptibility was observed within each region: AP (range, 50-100% S), AME (48-86.9%), EU (44.8-88%), LA (43-92%), and NA (74.5-91.6%). Voriconazole was more active than fluconazole (range, 82.3-84.2% S) with similar regional variation. Among 22 sentinel sites participating in ARTEMIS from 2001 through 2007 (84 140 total isolates, 8163 C. glabrata), the frequency of C. glabrata isolation increased in 14 sites and the frequency of fluconazole resistance (R) increased in 11 sites over the 7-year period of study. The sites with the highest cumulative rates of fluconazole R were in Poland (22% R), the Czech Republic (27% R), Venezuela (27% R), and Greece (33% R). C. glabrata was most often isolated from blood, normally sterile body fluids and urine. There is substantial geographic and institutional variation in both frequency of isolation and azole resistance among C. glabrata. Prompt species identification and fluconazole susceptibility testing are necessary to optimize therapy for invasive candidiasis.

Keywords

Africa, Americas, Antifungal Agents/pharmacology, Asia, Candida glabrata/drug effects, Candida glabrata/isolation & purification, Candidiasis/microbiology, Drug Resistance, Fungal, Europe, Fluconazole/pharmacology, Geography, Humans, Microbial Sensitivity Tests, Middle East, Pyrimidines/pharmacology, Triazoles/pharmacology

OAI-PMH

oai:serval.unil.ch:BIB_677592ECADCF

DOI

10.1016/j.diagmicrobio.2010.01.002

Pubmed

20338711

Web of science

000278194700007

Create date

23/06/2010 14:26

Last modification date

20/08/2019 15:23

Usage data

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Geographic variation in the frequency of isolation and fluconazole and voriconazole susceptibilities of Candida glabrata: an assessment from the ARTEMIS DISK Global Antifungal Surveillance Program.

Details