Outpatient Yttrium-90 microsphere radioembolization: assessment of radiation safety and quantification of post-treatment adverse events causing hospitalization.
Details
Serval ID
serval:BIB_6759AF918E4A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Outpatient Yttrium-90 microsphere radioembolization: assessment of radiation safety and quantification of post-treatment adverse events causing hospitalization.
Journal
La Radiologia medica
ISSN
1826-6983 (Electronic)
ISSN-L
0033-8362
Publication state
Published
Issued date
10/2020
Peer-reviewed
Oui
Volume
125
Number
10
Pages
971-980
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Quantification of post-interventional adverse events of outpatient SIRT leading to hospitalization and quantification of radiation exposure.
In this single-center, retrospective cohort study, we reviewed 212 patients treated with SIRT ( <sup>90</sup> Y-microspheres) for primary and secondary liver malignancies. We searched for adverse events (AEs) and serious adverse events (SAEs), defined as AE's causing hospitalization. Additionally, radiation exposure was measured in 36 patients.
Seven patients had an SAE (3.3%), four patients had AE without readmission/hospitalization (1.9%) and 201 patients had no complications (94.8%). The mean ambient dose rate at 1 m distance from the source after administration of <sup>90</sup> Y-microspheres was 1.88 µSv/h ± 0.74 (± SD) with a range from 4.3 to 0.2 µSv/h.
Outpatient radioembolization with <sup>90</sup> Y-microspheres is safe and requires hospitalization only in a very small number of patients. The mean dose rate was low and met the national conditions for outpatient treatment (< 5 µSv/h).
In this single-center, retrospective cohort study, we reviewed 212 patients treated with SIRT ( <sup>90</sup> Y-microspheres) for primary and secondary liver malignancies. We searched for adverse events (AEs) and serious adverse events (SAEs), defined as AE's causing hospitalization. Additionally, radiation exposure was measured in 36 patients.
Seven patients had an SAE (3.3%), four patients had AE without readmission/hospitalization (1.9%) and 201 patients had no complications (94.8%). The mean ambient dose rate at 1 m distance from the source after administration of <sup>90</sup> Y-microspheres was 1.88 µSv/h ± 0.74 (± SD) with a range from 4.3 to 0.2 µSv/h.
Outpatient radioembolization with <sup>90</sup> Y-microspheres is safe and requires hospitalization only in a very small number of patients. The mean dose rate was low and met the national conditions for outpatient treatment (< 5 µSv/h).
Keywords
Ambulatory Care, Angiography, Embolization, Therapeutic/adverse effects, Embolization, Therapeutic/methods, Female, Hospitalization/statistics & numerical data, Humans, Liver Neoplasms/blood supply, Liver Neoplasms/secondary, Liver Neoplasms/therapy, Male, Microspheres, Middle Aged, Outpatients, Radiation Exposure/analysis, Radiation Pneumonitis/prevention & control, Retrospective Studies, Single Photon Emission Computed Tomography Computed Tomography, Yttrium Radioisotopes/administration & dosage, Yttrium Radioisotopes/adverse effects, Outpatient, Patient safety, Radiation exposure, Radiation protection, SAE, SIRT
Pubmed
Web of science
Create date
21/04/2020 9:20
Last modification date
15/09/2020 5:26
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