Reversal of convention: from man to experimental animal in elucidating the function of the renal amiloride-sensitive sodium channel

Détails

ID Serval
serval:BIB_672E7971D70A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Reversal of convention: from man to experimental animal in elucidating the function of the renal amiloride-sensitive sodium channel
Périodique
Experimental Nephrology
Auteur(s)
Hummler  E.
ISSN
1018-7782 (Print)
Statut éditorial
Publié
Date de publication
08/1998
Volume
6
Numéro
4
Pages
265-71
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Jul-Aug
Résumé
The kidney plays a dominant role in maintaining sodium homeostasis. Despite wide variation in environmental exposure, the osmolality of the extracellular fluid that is determined by the sodium ion concentration is maintained within narrow margins. Derangement in function of proteins that transport Na+ and of those regulating the activity of these sodium-transporting proteins are likely to be responsible for a number of clinical disorders of fluid and electrolyte homeostasis. The amiloride-sensitive epithelial sodium channel (ENaC) is implicated in the control of blood pressure as demonstrated by the analysis of two genetic diseases, Liddle's syndrome and pseudohypoaldosteronism (PHA-1). Mutations have been identified in the genes coding for the alpha-, beta- or gamma-subunit of ENaC. ENaC constitutes the limiting step for sodium reabsorption in epithelial cells that line the distal nephron, distal colon, ducts of several exocrine glands and lung airways and might play an important role in pathophysiological and clinical conditions such as hypertension or lung edema.
Mots-clé
Amiloride/*pharmacology Animals Chromosome Mapping Disease Models, Animal Gene Targeting Homeostasis/physiology Humans Hypertension/genetics/metabolism Kidney/*metabolism Mutation/physiology Sodium Channels/*drug effects/genetics/*physiology
Pubmed
Web of science
Création de la notice
24/01/2008 13:42
Dernière modification de la notice
20/08/2019 15:22
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