Acute neurological disease as a trigger or co-occurrence of transient global amnesia: a case series and systematic review.

Details

Serval ID
serval:BIB_670D20418905
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Acute neurological disease as a trigger or co-occurrence of transient global amnesia: a case series and systematic review.
Journal
Neurological sciences
Author(s)
Piffer S., Nannoni S., Maulucci F., Beaud V., Rouaud O., Cereda C.W., Maeder P., Michel P.
ISSN
1590-3478 (Electronic)
ISSN-L
1590-1874
Publication state
Published
Issued date
10/2022
Peer-reviewed
Oui
Volume
43
Number
10
Pages
5959-5967
Language
english
Notes
Publication types: Journal Article ; Review ; Systematic Review
Publication Status: ppublish
Abstract
Transient global amnesia (TGA) represents a benign neurological syndrome of unknown pathophysiology, often accompanied by vanishing hippocampal punctate lesions on diffusion-weighted imaging (hippocampal punctate diffusion lesion, HPDL). The recent literature suggests that TGA may be triggered by acute neurological conditions.
To study patients with TGA triggered by an acute neurological disease.
We retrospectively reviewed patients from two neurology centres with TGA (with or without HPDL) in whom an acute neurological condition could be identified as trigger. We also performed a systematic review of the literature of this situation using predefined search terms.
We identified 38 patients (median age 62 years, 55.3% female): 6 from our centres and 32 from the literature. Acute neurovascular diseases that preceded or were associated with TGA included ischemic and haemorrhagic strokes, convexity subarachnoid haemorrhage, and reversible cerebral vasoconstriction syndrome. As non-vascular acute neurological diseases, we identified migraine and peripheral-origin vertigo. The clinical manifestation of the neurological trigger showed a variable temporal relation with TGA onset; in some cases preceding and in others co-occurring with TGA manifestation. In some cases, presumed neurological triggers were asymptomatic and diagnosed from the neuroimaging done for the TGA.
Acute vascular and non-vascular neurological events may trigger TGAs or may occur simultaneously. In the first case, such an acute neurological disease may activate direct pathways within the nervous systems leading to TGA, or alternatively elicit a bodily sympathetic overactivity cascade. In the second case, both neurological events may be the result of a common external stressor.
Keywords
Acute Disease, Amnesia, Transient Global/epidemiology, Female, Humans, Male, Middle Aged, Nervous System Diseases/complications, Nervous System Diseases/epidemiology, Retrospective Studies, Migraine, Transient global amnesia; Stroke; Subarachnoid haemorrhage, Vertigo
Pubmed
Web of science
Create date
26/07/2022 12:49
Last modification date
31/08/2023 5:59
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