Article: article from journal or magazin.
Toward improved immunocompetence of adoptively transferred CD8+ T cells.
Journal of Clinical Investigation
Adoptive transfer of autologous or allogenic T cells to patients is being used with increased frequency as a therapy for infectious diseases and cancer. However, many questions remain with regard to defining optimized procedures for preparation and selection of T cell populations for transfer. In a new study in this issue of the JCI, Gattinoni and colleagues used a TCR transgenic mouse model to examine in vitro-generated tumor antigen-specific CD8+ T cells at various stages of differentiation for their efficacy in adoptive immunotherapy against transplantable melanoma. The results confirm that CD8+ T cells progressively lose immunocompetence with prolonged in vitro cultivation and suggest that effector CD8+ T cells alone may be considerably less potent at protecting hosts with advanced tumors than are less differentiated T cells.
Animals, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/transplantation, Cell Differentiation/immunology, Humans, Immunity, Cellular, Immunotherapy, Adoptive, Melanoma/immunology, Melanoma/therapy, Mice, Neoplasms, Experimental/immunology, Transplantation, Autologous, Transplantation, Homologous
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